NCT04817072

Evaluation of Mood Disorders Under Biologics in Chronic Inflammatory Rheumatic Disease

Evaluation of Mood Disorders Under Biologics (Anti-TNF Alpha) in Chronic Inflammatory Rheumatic Disease

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 108 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Besancon · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Chronic inflammatory rheumatic diseases (CIRD) affect many organ systems. Painful sensations within the joints spine, hand and foot deformities, low quality of life and psychosocial status in patients with rheumatoid arthritis, spondyloarthritis and psoriatic arthritis can lead to the development of anxiety and depression. Prevalences of anxiety increase in patients suffering of CIRD, compared with healthy individuals. Another connection has been identified by the links between depression and systemic inflammation. It is proven that higher plasma levels of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFa) affect neurotransmitter metabolism, with influence on patients mood. The purpose of EMOTION study is therefore to analyze thymic variation under TNFa therapy, as treatment of CIRDs.

Conditions

• Rheumatic Diseases
• Mood Disorders

Interventions

Type	Name	Description
OTHER	Blood sample	Blood sample (20mL) for pro-inflammatory cytokines assay

Timeline

• Start date: 2021-05-19
• Primary completion: 2025-11-01
• Completion: 2026-05-01
• First posted: 2021-03-25
• Last updated: 2025-07-09

Locations

1 site across 1 country: France