NCT04807023

Decompensation of Cirrhosis and Iron Metabolism

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Rennes University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Iron is a crucial metal whose metabolism is tightly regulated. Iron deficiency or iron overload are both deleterious at the cellular, organic and systemic levels. In line with the major role of the liver in iron homeostasis, links between iron metabolism and acute on chronic liver failure have been highlighted. Nevertheless, due to the difficulty of accurately assessing iron metabolism in this situation, therapeutic intervention on iron metabolism in this setting is currently not codified. A better understanding of these mechanisms is therefore essential, in particular by characterizing the impact of exposure to non-transferrin-bound iron in acute on chronic liver failure on short-term mortality. Overall, a better understanding of the physiopathological mechanisms of iron should allow to optimize the martial balance in this condition and also improve therapeutic approaches.

Conditions

• Cirrhosis

Interventions

Type	Name	Description
BIOLOGICAL	blood sampling	blood sampling

Timeline

• Start date: 2021-05-17
• Primary completion: 2022-05-01
• Completion: 2022-11-01
• First posted: 2021-03-19
• Last updated: 2021-07-19

Locations

1 site across 1 country: France