NCT04803084

Multiparametric MRI as a Non-Invasive Biomarker of the Tumor Microenviroment

Multiparametric MRI as a Non-Invasive Biomarker of the Tumor Microenviroment in Breast Cancer

• Status: Suspended
• Phase: —
• Study type: Observational
• Enrollment: 10 (estimated)
• Sponsor: Laura Kennedy · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is looking at how an imaging test could help doctors understand if a patient with early breast cancer will respond to drugs that use the patient's immune system to fight cancer.

Detailed description

Primary Objective: \- To evaluate serial multiparametric MRI as an early marker for tumor immune response to an immune checkpoint inhibitor agent Secondary Objective: * To assess the potential of early treatment imaging changes on MRI to discern final tumor treatment response * To assess the prognostic potential of MRI features Correlative: * To correlate MRI features with immunophenotypes (i.e. hot and cold tumors) * To evaluate the association of MRI features with other known biomarkers of immune checkpoint inhibitor response

Conditions

• Breast Cancer
• Triple-negative Breast Cancer

Interventions

Type	Name	Description
OTHER	Tempus assay	Blood collection
OTHER	Advanced pathology 1	Tissue procurement (from diagnostic biopsy)
OTHER	Advanced pathology 2	Tissue procurement (from research biopsy)

Timeline

• Start date: 2021-08-09
• Primary completion: 2025-08-01
• Completion: 2025-08-01
• First posted: 2021-03-17
• Last updated: 2024-11-20

Locations

1 site across 1 country: United States