Trials / Withdrawn
WithdrawnNCT04802928
Healing of Ischemic Leg Ulcers in Patients Treated With iSONIAzid
Healing of Ischemic Leg Ulcers: A Pilot Trial
- Status
- Withdrawn
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 0 (actual)
- Sponsor
- Pharma 2100 · Industry
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The main objective of this trial is to study the healing effect of an oral drug (isoniazid) in patients with ischemic (arterial) leg ulcers defined by a systolic toe pressure \<40 mm Hg.
Detailed description
Treatment of arterial ulcers is problematic. Previous pharmaceutical interventions with for example prostaglandins have produced only limited beneficial effects but have been associated with frequent adverse effects. Positive effects of isoniazid have been observed in a preclinical model of ischemic wound healing (Weinreich et al. Surgery 2010).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Isoniazid 300 milligram | Tablets 150 milligram b.i.d. |
| DRUG | Placebo | Placebo |
Timeline
- Start date
- 2008-04-01
- Primary completion
- 2008-09-01
- Completion
- 2008-11-01
- First posted
- 2021-03-17
- Last updated
- 2021-03-19
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT04802928. Inclusion in this directory is not an endorsement.