NCT04802889

Microarchitecture of Vitreoretinal Contact

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: The S.N. Fyodorov Eye Microsurgery State Institution · Other Government
• Sex: All
• Age: 35 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Investigation of the vitreoretinal contact microarchitecture in the macular and paramacular zones of the human retina.

Detailed description

Purpose: to study the features of the macular ILM, to study the features of the preretinal structures of the vitreous body of the Central retinal region, morphofunctional features of preretinal hyalocytes, and the mechanism of vitreoretinal adhesion. Study Protocol: examination of donor human eyes obtained from an eye Bank after sampling material for corneal transplantation. Research method: scanning electron microscopy (SEM) of the central retina (macular and paramacular zone): ILM, preretinal vitreous. Scientific hypothesis: vitreoretinal adhesion is provided not by laminin and fibronectin, but by the interweaving of vitreous collagen fibers between the epiretinal vitreous (more firmly fixed to the retinal surface) and the cortical vitreous. Expected results: determination of ILM thickness in the macular zone, microanatomy of preretinal vitreous strutcures, and possible mechanism of vitreoretinal adhesion, establishing the possibility of intravital synthesis of collagen fibers synthesis in the adult vitreous.

Conditions

• Vitreoretinal Detachment
• Vitreo-Retinal Adhesion

Interventions

Type	Name	Description
OTHER	scanning electron microscopy	scanning electron microscopy of the сentral retina and preretinal structures

Timeline

• Start date: 2008-01-01
• Primary completion: 2020-01-01
• Completion: 2020-12-31
• First posted: 2021-03-17
• Last updated: 2021-03-17

Locations

1 site across 1 country: Russia