NCT04802668

Factors Influencing of Pulse Pressure Variation (PPV)

Factors Influencing the Reliability of Pulse Pressure Variation (PPV) as a Predictor of Fluid Responsiveness in Mechanically Ventilated Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 189 (actual)
• Sponsor: Southeast University, China · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.

Detailed description

PPV can be used to predict fluid responsiveness in patients with circulatory shock.However, it is affected by many factors, which leads to the decrease of the applicability of PPV in ICU.Therefore, the investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.

Conditions

• Haemodynamics
• Fluid Responsiveness
• Pulse Pressure Variation

Interventions

Type	Name	Description
DEVICE	Patients were ventilated with assist-control ventilation（A/C） mode at different tidal volume	Ventilation mode was set to assist-control volume ventilation with different tidal volume, respiratory frequency 15 times/min, PEEP 5 centimeter water column.
BEHAVIORAL	spontaneous breathing and no spontaneous breathing	Data were recorded when patients had and did not have spontaneous breathing

Timeline

• Start date: 2021-03-20
• Primary completion: 2022-03-30
• Completion: 2022-07-30
• First posted: 2021-03-17
• Last updated: 2023-01-10

Locations

1 site across 1 country: China