NCT04796363

US Guided Erector Spinae Plane Block in Breast Cancer Surgery: Analgesia, Spread and Immunomodulation

Ultrasound Guided Erector Spinae Plane Block in Breast Cancer Surgery: Analgesia, Spread and Immunomodulation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Alexandria University · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Prospective interventional study

Detailed description

The aim of the present study is to evaluate the effect of US guided unilateral ESPB using different volumes of local anaesthetics on analgesic efficacy, dermatomal spread and immunomodulation in breast cancer surgery. The primary outcome is the analgesic efficacy of the different local anaesthetic volumes of ESPB. The secondary outcomes are the dermatomal dye spread and sensory coverage, immunomodulation and complications in breast cancer surgery. Immunomodulation will be assessed by measuring Natural killer cells cytotoxicity.

Conditions

• Analgesia
• Breast Cancer

Interventions

Type	Name	Description
PROCEDURE	Erector Spinae Plane Block with Bubivacaine	Erector Spinae Plane Block with Bubivacaine 0.25% or 0.125% before breast cancer surgery
PROCEDURE	Standard General Anaesthesia	Standard General Anaesthesia without ESPB

Timeline

• Start date: 2020-11-25
• Primary completion: 2022-01-11
• Completion: 2022-01-21
• First posted: 2021-03-12
• Last updated: 2022-04-11

Locations

1 site across 1 country: Egypt