NCT04794634

Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 55 (actual)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Alzheimer disease is hard, long and expensive to diagnose. In order to help the clinician, a new biomarker in Alzheimer disease seems to be very useful. The retina, as a window of the brain, could offer a new way to diagnose this common disease. Indeed, a retinal atrophy could especially appear in Alzheimer disease. Besides, many aspects about retinal alteration, visual function and their link with the disease deserve to be more explored. So as to fill these gaps, a new study about retinal specificity in Alzheimer disease appears to be relevant.

Conditions

• Optical Coherence Tomography
• Optical Coherence Tomography Angiography
• Retinal Thickening
• Alzheimer Disease
• Lewy Body Disease
• Retina
• Cortical Atrophy
• Retinal Nerve Fibres Layer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Optical coherence tomography (OCT)	to make a complete ophthalmological and neurological examination, an OCT to AD and to compare their results with LD and controls subjects
DIAGNOSTIC_TEST	Optical coherence tomograpohy angiography (OCTA)	to make a complete ophthalmological and neurological examination, an OCT and OCTA, to AD and to compare their results with LD and controls subjects

Timeline

• Start date: 2021-01-13
• Primary completion: 2023-06-23
• Completion: 2025-12-01
• First posted: 2021-03-12
• Last updated: 2025-12-08

Locations

1 site across 1 country: France