NCT04792762

Physiology of GIP(1-30)NH2 in Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: Male
• Age: 20 Years – 30 Years
• Healthy volunteers: Accepted

Summary

Glucose-dependent insulinotropic polypeptide (GIP) is a gut-derived incretin hormone that affects glucose, lipid and bone metabolism. Secretion of GIP into the blood stream from enteroendocrine cells is stimulated bu nutrients in the gut lumen and results in potentiation of glucose stimulated insulin secretion from the pancreas. The objective of this study is to investigate the physiology of GIP(1-30)NH2 in humans with insulin secretion as the primary endpoint. Furthermore the effects on on plasma/serum levels of glucagon, C-peptide, glucose, bone markers (CTX and P1NP) will be measured.

Conditions

• Glucose Metabolism Disorders

Interventions

Type	Name	Description
OTHER	GIP(1-30)NH2	Intravenous administration of the peptide hormone GIP(1-30)NH2 during a stepwise glucose clamp
OTHER	GIP(1-42)	Intravenous administration of the peptide hormone GIP(1-42) during a stepwise glucose clamp
OTHER	Saline	Intravenous administration of saline during a stepwise glucose clamp

Timeline

• Start date: 2018-06-12
• Primary completion: 2018-08-23
• Completion: 2019-06-09
• First posted: 2021-03-11
• Last updated: 2021-03-11

Locations

1 site across 1 country: Denmark