NCT04792424

No Monitoring of Post-filter Ionized Calcium in Regional Citrate Anticoagulation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Chulalongkorn University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Do no monitor of post-circuit ionized calcium affact the filter life time of continueous renal replacement therapy with regional citrate anticoagulation circuit? A randomized control trial

Detailed description

Regional citrate anticoagulation is the gold standard of anticoagulation in patient receiving CRRT. In RCA circuit, there was a monitoring of pre-filter (systemic) ionized calcium and post-filter (circuit) ionized calcium. Pre-filter ionized calcium was monitored for observe the adverse effect of citrate such as hypocalcemia, citrate intoxication. However, post-filter ionized calcium was monitored for adjustment the citrate dose. We find many problem with frequently monitoring of post-ionized calcium such as confusion from markedly abnormal result, how to adjustment the citrate dose ,and increase workload for nurses. We hypothesis that if we can monitoring of post-filter ionized calcium?

Conditions

• Regional Citrate Anticoagulation
• Ionized Calcium
• Continuous Renal Replacement Therapy

Interventions

Type	Name	Description
OTHER	Regional citrate anticoagulation	Starting RCA 4 mmol/L (adjust the rate by BFR)
DRUG	Vasopressor	Vasopressors such as Norepinephrine, dopamine, milrinone, dobutamine
DRUG	Antibiotic	Antibacterial agents deemed appropriate by physicians in the ICU
DEVICE	Dialysis with continuous renal replacement therapy	Prismaflex

Timeline

• Start date: 2021-04-01
• Primary completion: 2022-05-30
• Completion: 2022-06-15
• First posted: 2021-03-11
• Last updated: 2022-11-14

Locations

1 site across 1 country: Thailand