NCT04792138

Learning MRI and Histology Image Mappings for Cancer Diagnosis and Prognosis.

Learning MRI and Histology Image Mappings for Cancer Diagnosis and Prognosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: University College, London · Academic / Other
• Sex: Male
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Multiparametric magnetic resonance imaging (mpMRI) is now widely used to risk stratify men with a suspicion of prostate cancer and identify suspicious regions for biopsy. Advanced MRI techniques have emerged which seek to improve this characterisation and could predict biopsy results non-invasively before men undergo biopsy. Before these techniques are translated clinically, robust histological and clinical validation is required. This study aims to clinically validate advanced MRI techniques in a cohort of men suspected with prostate cancer. Histological analysis of men undergoing biopsy, +/- prostatectomy will be used for biological validation of VERDICT; Vascular and Extracellular Restricted Diffusion for Cytometry in Tumours and Luminal Water imaging (LWI). In particular, prostatectomy specimens will be processed using 3-D printed patient-specific moulds to allow for accurate MRI and histology mapping.

Conditions

• Prostate Cancer
• Prostate Neoplasm

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	VERDICT MRI	Advanced Diffusion Model
DIAGNOSTIC_TEST	Luminal Index Imaging	Advanced T2 mapping

Timeline

• Start date: 2020-10-23
• Primary completion: 2022-10-01
• Completion: 2023-10-01
• First posted: 2021-03-10
• Last updated: 2021-03-10

Locations

1 site across 1 country: United Kingdom