NCT04787822

Long Term Follow up of the LTOG Cohort

Long Term Follow up of the Lung Transplant Outcomes Group Cohort

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 4,000 (estimated)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 13 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to follow participants who enrolled in the Lung Transplant Outcomes Group. Clinical data, functional assessments, and surveys will be collected to determine long term graft function and functional status of lung transplant recipients.

Detailed description

This project will involve both retrospective and prospective data collection from participants enrolled in the LTOG cohort studies. We will perform long-term Chronic Lung Allograft Dysfunction (CLAD) phenotyping of lung transplant recipients who participated in the LTOG cohort studies utilizing data collected for routine clinical visits. Surviving lung transplant recipients who participated in the LTOG cohort studies will be recruited to enroll in the longitudinal portion of the project. The longitudinal component will include follow-up data collection at 6 month intervals while alive until study termination, study withdrawal, or no longer being seen for follow-up at the participating center. Follow-up data collection will include clinical data collected by study coordinators by reviewing medical records, functional assessment through administration of the Short Physical Performance Battery (SPPB), blood collection and surveys. Data from this project will be linked to data and samples collected during the LTOG cohort or ancillary studies.

Conditions

• Lung Transplant Failure and Rejection

Timeline

• Start date: 2021-06-15
• Primary completion: 2026-05-31
• Completion: 2026-05-31
• First posted: 2021-03-09
• Last updated: 2025-05-29

Locations

10 sites across 1 country: United States