Trials / Completed
CompletedNCT04785053
Memory Functions in Mild Alzheimer's Disease
Improving Memory Functions in Mild Alzheimer's Disease by Transcranial Alternating Current Stimulation
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 34 (actual)
- Sponsor
- Hebrew SeniorLife · Academic / Other
- Sex
- All
- Age
- 21 Years
- Healthy volunteers
- Accepted
Summary
The overall objective of this project is to examine the effects of non-invasive brain stimulation on episodic memory performance
Detailed description
A group of 20 cognitively intact younger participants (age 21-35), a group of 20 cognitively intact older participants (age 55+) and an age-matched group of 20 MCI/mild AD participants will be enrolled in the brain stimulation study with behavioral assessments at baseline and post-intervention. All participants will perform a laboratory-based memory task and an autobiographical memory task, followed by the autobiographical interview after the tACS intervention. Each participant will undergo three experimental sessions, applying 20-minute gamma tACS stimulation, theta tACS stimulation or an active sham (control) to the left angular gyrus. Before, during, and after the brain stimulation scalp high-density 257-channels EEG will be recorded to characterize and differentiate brain activity and regional interactions in the three independent groups.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | transcranial alternating current stimulation (tACS) | The tACS intervention (gamma stimulation, theta stimulation and active sham condition) will be administered to the participants over three visits that will be completed within one of the working days (Mon-Fri) at approximately the same time of day for all participants. Participants will be randomized and blinded to the tACS treatment. |
Timeline
- Start date
- 2020-06-22
- Primary completion
- 2023-09-30
- Completion
- 2023-09-30
- First posted
- 2021-03-05
- Last updated
- 2024-06-26
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated device study
Source: ClinicalTrials.gov record NCT04785053. Inclusion in this directory is not an endorsement.