NCT04784975

Bone Health and Microbiome in Persons With Type 1 Diabetes

Bone Health and Gut Microbiome in Persons With Preclinical and Clinical Type 1 Diabetes

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 26 (actual)
• Sponsor: Indiana University · Academic / Other
• Sex: All
• Age: 12 Years – 20 Years
• Healthy volunteers: Accepted

Summary

It is well-established that persons with type 1 diabetes (T1D) are at an increased risk for morbidity and mortality related to bone fracture due to poor bone health, however we do not fully understand the mechanism behind the increased fracture risk. We are examining bone health and the microbiome in adolescents and young adults with type 1 diabetes to better understand the reasons behind this increased risk.

Detailed description

This pilot study aims to look at measures of bone health, the gut microbiome and measures of glycemia/glycemic variability in those with preclinical and clinical diabetes. Our primary and secondary outcomes are to characterize these variables, with our long term objectives to better understand the natural history of bone health in T1D, help characterize the etiology of worse bone health in those with T1D, and try to identify potential time periods for intervention.

Conditions

• Type1diabetes

Interventions

Type	Name	Description
OTHER	No intervention	No intervention

Timeline

• Start date: 2021-04-23
• Primary completion: 2022-09-23
• Completion: 2022-09-23
• First posted: 2021-03-05
• Last updated: 2023-02-28

Locations

1 site across 1 country: United States