NCT04784468

DNA Damage and Oxidative Stress in Hospitalized COVID-19 Patients

DNA Damage and Oxidative Stress in Hospitalized COVID-19 Patients Compared to Healthy Controls: A Case-control Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 135 (estimated)
• Sponsor: University of Vienna · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic challenging health systems worldwide. While there is a clear correlation between oxidative stress markers and the severity of many viral diseases such as hepatitis C, for SARS-CoV clinical data is limited. The investigators aim at 1.) investigating DNA damage, oxidative stress, inflammation, and aging markers in COVID-19 patients and compare them with age and gender matched healthy controls and patients with influenza; and 2.) investigating all aforementioned parameters during "cytokine storm" via repeated blood sampling.

Conditions

• Covid19

Interventions

Type	Name	Description
OTHER	No intervention	Case-control design, one single investigation

Timeline

• Start date: 2020-11-19
• Primary completion: 2021-03-31
• Completion: 2021-09-30
• First posted: 2021-03-05
• Last updated: 2021-03-09

Locations

1 site across 1 country: Austria