NCT04784221

Nanoparticles and Hypofractionated Protontherapy for Reirradiation of Pantumor Relapse

Nanoparticles and Hypofractionated Protontherapy for Reirradiation of Pantumor Relapse: NANOPRO, a Non-randomized Phase II Study

• Status: Withdrawn
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Centre Francois Baclesse · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective multicenter non-randomized phase II study: proton therapy with nanoparticles based on polysiloxane and gadolinium chelates injectable intravenously

Detailed description

This is a prospective multicenter non-randomized phase II study: proton therapy with nanoparticles based on polysiloxane and gadolinium chelates injectable intravenously in recurrent tumors

Conditions

• Recurrent Cancer
• Previous Radiation

Interventions

Type	Name	Description
RADIATION	Radiation by protontherapy associated to nanoparticles injection	Treatment for the study will be based on proton therapy and the administration of AGuIX® nanoparticles. Protontherapy will be carried out for 4 consecutive weeks with 5 sessions per week (20 sessions) from D1 to D26. The administration of the AGuIX® nanoparticle will be done on Days 1, 8 and 15 during protontherapy

Timeline

• Start date: 2021-03-01
• Primary completion: 2027-09-01
• Completion: 2027-09-01
• First posted: 2021-03-05
• Last updated: 2025-09-17