NCT04782531

Variations of Portal Flow During the Respiratory Cycle in Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The analysis of portal vein blood flow is important when assessing the severity and progression of liver disease. It is important to understand normal liver regulation in order to appreciate the evaluation of the effect of treatment during the disease progression. The influence of respiration on hepatic hemodynamics is still poorly understood, although some studies have shown a significant impact. The purpose of this project is to quantify the blood flow variations in the portal vein at different positions during the respiratory cycle by using a fast MRI sequence and an Echo Planar (EPI) acquisition.

Conditions

• Respiratory Amplitude
• Portal Blood Flow
• MRI
• Echo Planar Imaging

Interventions

Type	Name	Description
OTHER	peripheral ECG	Subjects will be placed in supine position. The systematic use of a headset will reduce the noise inherent to the machine. A cardiac synchronization system using peripheral ECG allows the synchronization with the subject's heart rate.
OTHER	Standard MRI	Standard MRI examination using a torso coil consists of morphological and phase-contrast flow sequences(standard and EPI acquisitions).

Timeline

• Start date: 2021-03-01
• Primary completion: 2023-03-01
• Completion: 2024-10-07
• First posted: 2021-03-04
• Last updated: 2025-05-29

Locations

1 site across 1 country: France