NCT04781595

Watermelon and Beetroot Products on Endothelial Function

Effect of Watermelon and Beetroot Products on Endothelial Function in Young and Older Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Universidade Federal do Rio de Janeiro · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Cardiovascular disease is the main cause of death worldwide. Endothelial dysfunction is the first step to development of cardiovascular diseases. Endothelial dysfunction occurs due to reduction in nitric oxide, a molecule that plays an important role on vascular health. Due to important role of nitric oxide in endothelial function, several studies have evaluated the effect of its precursors, such as L-citrulline and nitrate on endothelial function parameters. The present study will evaluate the effect of L-citrulline and nitrate derived by watermelon and beetroot products, respectively, on endothelial function of young and older participants. Furthermore, we will evaluate the plasmatic amino acids, nitrate, glucose and insulin in response to ingestion of these products.

Conditions

• Healthy Young
• Older People With Cardiovascular Disease Risk

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Watermelon	A single dose of watermelon powder containing 3g of L-citrulline
DIETARY_SUPPLEMENT	Beetroot	A single dose of beetroot powder containing 8 mmol of nitrate
DIETARY_SUPPLEMENT	Watermelon + beetroot	A single dose of watermelon and beetroot powder containing 3g of L-citrulline and 8 mmol of nitrate
DIETARY_SUPPLEMENT	Placebo	A single dose of maltodextrin

Timeline

• Start date: 2021-03-01
• Primary completion: 2022-06-30
• Completion: 2022-07-31
• First posted: 2021-03-04
• Last updated: 2022-12-22

Locations

1 site across 1 country: Brazil