NCT04781153

Bergen Oral Respiratory Intervention Study

The Impact of Oral Bacteria on Lung Function and Inflammation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 62 (actual)
• Sponsor: Anders Røsland · Academic / Other
• Sex: All
• Age: 25 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate if treatment of periodontitis (gum disease) in a relatively young and healthy population can improve lung function. It is hypothesized that removing the dental biofilm reduce the source of inflammatory bacteria that can reach the lungs, and thereby reduce lung inflammation and lead to improved lung function.

Detailed description

After being informed about the study and potential risks, all participants giving written informed consent will undergo a clinical screening to determine eligibility for study entry. The study participants will be randomized into two groups. Half of the study participants will after baseline move directly into an active periodontal treatment phase including oral hygiene instructions and professional tooth cleaning by a full mouth disinfection protocol (intervention 2). New data will be collected after 6-8 weeks of healing. The second study group will after baseline receive prophylactic periodontal treatment by oral hygiene instructions and supragingival plaque removal (intervention 1). New data will be collected after 3-4 weeks. This group will now receive the active periodontal treatment phase (intervention 2) like the first study had initially. New data will be collected after 6-8 weeks of healing. Both groups will receive supportive periodontal treatment every 3 months in 12 months after intervention 2.

Conditions

• Periodontitis
• Airway Obstruction
• Lung Inflammation

Interventions

Type	Name	Description
PROCEDURE	Periodontal treatment	Periodontal treatment (scaling and rootplaning) with adjunctive chlorhexidine use

Timeline

• Start date: 2021-04-27
• Primary completion: 2024-06-27
• Completion: 2024-06-27
• First posted: 2021-03-04
• Last updated: 2025-02-06

Locations

1 site across 1 country: Norway