NCT04777214

TMS in Aphasia Recovery

A Blinded Randomized Sham-Controlled Incomplete Crossover Trial of Low-Frequency Contralesional Repetitive Transcranial Magnetic Stimulation in the Treatment of Aphasia in Patients With Chronic Stroke

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Stroke often causes substantial problems in speaking or understanding speech. Treatments for these problems are currently very limited. Limited studies to date suggest that repetitive Transcranial Magnetic Stimulation (TMS) to the side of the brain opposite to the side on which the stroke occurred may improve language function. The investigators are testing this hypothesis by giving daily 20 minute sessions of repeated TMS to the right (unaffected) side of the brain; the investigators test language function with a variety of tests both before and after the treatment with TMS and subjects are required to undergo functional MRI scans before and after treatment. TMS is a procedure in which a coil is placed next to the head of the subject and an electrical current passes through the coil causing a magnetic field that, in turn, causes a small electric current in the portion of the brain underneath the coil.

Conditions

• Aphasia

Interventions

Type	Name	Description
DEVICE	Repetitive Transcranial Magnetic Stimulation	Active TMS will be at 90% motor threshold
DEVICE	Sham TMS	Sham TMS will be administered

Timeline

• Start date: 2007-06-26
• Primary completion: 2011-08-30
• Completion: 2011-08-30
• First posted: 2021-03-02
• Last updated: 2021-11-26
• Results posted: 2021-11-26

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study