NCT04775394

Activation of Apoptosis-related Receptors on Alveolar Macrophages

Activation of Apoptosis-related Receptors on Alveolar Macrophages From COPD Patients and Healthy Controls

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Prof. Dr. Jens Hohlfeld · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The aim is to understand whether activation of receptors involved in clearance of apoptotic cells will improve efferocytosis in COPD patients in vitro and whether generation of pro-inflammatory cytokines can be decreased in COPD patients.

Detailed description

In order to assess pathway activation in COPD macrophages, alveolar macrophages will be isolated from BAL of COPD patients and healthy controls. Alveolar macrophages will be co-cultured in vitro with apoptotic cells and treated with compounds. In addition, BAL fluid will be frozen for later testing of soluble mediators.

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

Type	Name	Description
OTHER	Bronchoscopy	Bronchoalveolar lavage, mucosal biopsy and bronchial brushes during bronchoscopy

Timeline

• Start date: 2021-01-01
• Primary completion: 2023-07-21
• Completion: 2023-07-21
• First posted: 2021-03-01
• Last updated: 2023-08-01

Locations

1 site across 1 country: Germany