Trials / Unknown
UnknownNCT04772794
Immunologic Effect of Fraction of Inspired Oxygen
Immunological Effect of Intraoperative Fraction of Inspired Oxygen in Patients Undergoing Major Abdominal Cancer Surgery
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- Sponsor
- Assiut University · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
During anesthesia and surgery, oxygen is routinely administered to all patients. Inspired oxygen concentrations, however, vary between 30% - 100% and oxygen is often administered in a seemingly random manner.
Detailed description
During anesthesia and surgery, oxygen is routinely administered to all patients. Inspired oxygen concentrations, however, vary between 30% - 100% and oxygen is often administered in a seemingly random manner.A striking conundrum is evident immediately when one review studies on the effects of oxygen on cytokines synthesis. Most investigators have found that hyperoxia enhances proinflammtory cytokines transcription and translations (11). In contrast, hyperparic oxygen has generally been shown to suppress stimulus induced porinflammtory cytokine production (12). Other studies have demonstrated that supplemental oxygen improves inflammatory and immune function (13), and it is not associated with clinically important side effect (14). We therefor undertook the current prospective randomized study to investigate whether perioperative supplemental oxygen (30% versus 80%) on pro and anti-inflammatory response in patients undergoing major abdominal cancer surgeries as our primary outcome.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | fraction of inspired oxygen | after induction of general anaesthesia, different fraction of inspired oxygen will be given to patient according to their group allocation |
Timeline
- Start date
- 2020-01-13
- Primary completion
- 2022-01-01
- Completion
- 2022-05-01
- First posted
- 2021-02-26
- Last updated
- 2021-02-26
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT04772794. Inclusion in this directory is not an endorsement.