NCT04772092

Impact of Age and Geriatric Co-morbidities on Lymphocyte Phenotype in Patients 70 Years of Age and Older

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Centre Hospitalier Universitaire Dijon · Academic / Other
• Sex: All
• Age: 70 Years
• Healthy volunteers: —

Summary

An individual's immune profile changes with age, and can sometimes be involved in the development of certain diseases such as infections or cancers, in a process called immunosenescence. Some data tend to show that there is a link between this immune profile and geriatric fragility (autonomy, difficulties with walking, memory, undernutrition, co-morbidities, depression). The aim of this study is to describe this profile, or immune phenotype, and to see if there is a link with the different aspects of geriatric assessment in patients without cancer or infection. In addition, these data will serve as a basis for comparison with the same analyses performed on breast cancer patients at the Centre Georges François Leclerc.

Conditions

• Geriatrics Immunosenescence

Interventions

Type	Name	Description
BIOLOGICAL	Blood samples	during the routine blood test, collection of additional blood samples: * 1 x 5 mL heparinized tube for plasma collection and storage * 1 heparinized 5 mL tube for immunophenotyping * 4 x 10 mL EDTA tubes for white blood cell (WBC) collection and cryopreservation
OTHER	Data collection	* clinical examination data * test results to measure the degree of geriatric fatigability * Frailty screening questionnaire for neoplasia patients (G8 score)

Timeline

• Start date: 2021-11-01
• Primary completion: 2021-11-01
• Completion: 2021-11-01
• First posted: 2021-02-26
• Last updated: 2022-09-08