NCT04771884

Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Shandong University · Academic / Other
• Sex: All
• Age: 2 Months – 18 Years
• Healthy volunteers: Not accepted

Summary

The investigator's purpose is to study the population pharmacokinetics of commonly used antimicrobial agents in children of bacterial meningitis with augmented renal clearance and assess dosage individualization feasibility.

Detailed description

The investigator's purpose is to study the population pharmacokinetics of meropenem, vancomycin, ceftazidime, ceftriaxone, ceftizoxime and linezolid in children of bacterial meningitis with augmented renal clearance and assess dosage individualization feasibility. In this study, the investigator will detect drug concentration in both plasma and cerebrospinal fluid to construct population pharmacokinetics.

Conditions

• Bacterial Meningitis
• Augmented Renal Clearance

Interventions

Type	Name	Description
DRUG	meropenem vancomycin ceftazidime ceftriaxone ceftizoxime linezolid	The use of antimicrobial agents depends on the clinical practice

Timeline

• Start date: 2020-10-01
• Primary completion: 2026-01-20
• Completion: 2026-03-20
• First posted: 2021-02-25
• Last updated: 2021-04-13

Locations

1 site across 1 country: China

Regulatory

• FDA-regulated drug study