NCT04771104

The Effect of Induced Hyperammonaemia on Sleep and Melanopsin-mediated Pupillary Light Response in Patients With Liver Cirrhosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Sleep disturbances are common among patients with liver cirrhosis, but the reasons are not well understood. In this project the investigators evaluated whether an increase in blood ammonia in patients with cirrhosis had an impact on sleep quality and the function of retinal ganglion cells measured by pupillary response to blue light.

Conditions

• Hepatic Encephalopathy
• Liver Cirrhosis
• Sleep Disturbance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Amino Acid Challenge (AAC)	The AAC contains 54 g banana flavoured amino acid mixture added 200-300 mL of water. The AAC simulates the composition of haemoglobin in approximately 400 mL of blood.

Timeline

• Start date: 2017-01-01
• Primary completion: 2018-01-09
• Completion: 2018-01-22
• First posted: 2021-02-25
• Last updated: 2021-03-16

Locations

1 site across 1 country: Denmark