NCT04770207

Intra-tumor Injection of Drug-eluting Microspheres With Multiple Drugs

Intra-tumor Injection of Drug-eluting Microspheres Loading With Chemodrug Plus Checkpoint Inhibitors and/or IL2 for Treatment of Advanced Solid Tumors

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Second Affiliated Hospital of Guangzhou Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

To study the safety and clinical effect of injection of drug-eluting microspheres with multiple chemodrug and/or protein drugs into advanced solid tumors.

Detailed description

Drug-eluting microspheres such as DC-beads will be loaded with IL2, PD1/PDL1/CTLA4 antibody, or /and VEGF/VEGFR antibody with or without doxorubicin/idarubicin for various time and injected into tumors under CT guidance. Side effects and treatment efficacy after injection of drug-eluting microspheres into malignant tumors will be assessed according to RICEST1.1 standard.

Conditions

• Hepatocellular Carcinoma
• Solid Tumor, Adult

Interventions

Type	Name	Description
DRUG	Injection of drug-eluting microspheres with multiple drugs into solid tumors	Under the guidance of CT, puncture fine needle was used to inject drug-eluting microspheres loading with multiple drugs into the tumor

Timeline

• Start date: 2020-11-01
• Primary completion: 2029-11-01
• Completion: 2035-11-01
• First posted: 2021-02-25
• Last updated: 2024-08-21

Locations

1 site across 1 country: China