NCT04767347

Renal Considerations in the Heat Stress Recommendations

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: Indiana University · Academic / Other
• Sex: All
• Age: 18 Years – 44 Years
• Healthy volunteers: Accepted

Summary

An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused by increases in body temperature and dehydration. The current heat stress recommendations for workers were not developed with regards for kidney health. The purpose of this study is to determine if the current recommendations protect against kidney dysfunction.

Conditions

• Hot Weather; Adverse Effect
• Kidney Dysfunction
• Kidney Injury
• Hyperthermia
• Dehydration

Interventions

Type	Name	Description
OTHER	23.0°C WBGT - Fixed Work Rate	For four hours, participants will walk on a treadmill to elicit 430 W of metabolic heat production in the following conditions: 23.0°C WBGT (29°C, 46% relative humidity) @ 60 min exercise per hour
OTHER	25.5°C WBGT - Fixed Work Rate	For four hours, participants will walk on a treadmill to elicit 430 W of metabolic heat production in the following conditions: 25.5°C WBGT (31°C, 52% relative humidity) @ 45 min exercise per hour
OTHER	27.5°C WBGT - Fixed Work Rate	For four hours, participants will walk on a treadmill to elicit 430 W of metabolic heat production in the following conditions: 27.5°C WBGT (33°C, 53% relative humidity) @ 30 min exercise per hour
OTHER	28.5°C WBGT - Fixed Work Rate	For four hours, participants will walk on a treadmill to elicit 430 W of metabolic heat production in the following conditions: 28.5°C WBGT (34°C, 54% relative humidity) @ 15 min exercise per hour
OTHER	35.5°C WBGT - Fixed Work Rate	For four hours, participants will walk on a treadmill to elicit 430 W of metabolic heat production in the following conditions: 35.5°C WBGT (40°C, 65% relative humidity) @ 15 min exercise per hour
OTHER	26.0°C WBGT - Fixed work-to-rest ratio	For four hours, participants will walk on a treadmill at differing levels of metabolic heat production and environmental conditions (noted below), but at a fixed work-rest ratio of 30 minutes per hour. 26.0°C WBGT (31°C, 55% relative humidity) @ 530 W metabolic heat production
OTHER	30.5°C WBGT - Fixed work-to-rest ratio	For four hours, participants will walk on a treadmill at differing levels of metabolic heat production and environmental conditions (noted below), but at a fixed work-rest ratio of 30 minutes per hour. 30.5°C WBGT (36°C, 55% relative humidity) @ 230 W metabolic heat production
OTHER	30.5°C WBGT - Fixed work-to-rest ratio (high intensity)	For four hours, participants will walk on a treadmill at differing levels of metabolic heat production and environmental conditions (noted below), but at a fixed work-rest ratio of 30 minutes per hour. 30.5°C WBGT (36°C, 55% relative humidity) @ 530 W metabolic heat production

Timeline

• Start date: 2021-03-01
• Primary completion: 2023-05-04
• Completion: 2023-05-04
• First posted: 2021-02-23
• Last updated: 2023-11-08

Locations

1 site across 1 country: United States