NCT04764981

Olfactory Training for Olfactory Dysfunction After Coronavirus Disease - 19 (COVID-19)

Clinical Outcomes of Olfactory Training for Treatment of Olfactory Dysfunction After COVID-19

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 350 (estimated)
• Sponsor: Universidade do Estado do Pará · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

It is a randomized controlled clinical trial study that aims to follow a sample of individuals with persistent olfactory dysfunction post-COVID-19. The aim of this study is assess the clinical outcomes of olfactory training therapy in the treatment of persistent olfactory dysfunctions after COVID-19. The sample will consist of 350 participants, being 300 individuals with persistent olfactory dysfunction post-COVID-19 and 50 healthy individuals. Volunteers' will be separated in two experimental groups (1 and 2 ) and a control group. All participants will be submitted to clinical evaluation that include the Connecticut Chemosensory Clinical Research Test (CCCRT), an olfactory test to diagnose anosmia and hyposmia, and two skull Magnetic Resonance imaging (MRI). Only participants of Experimental group 1 will be submitted to an olfactory training with essences oils. Experimental group 2 will only receive a clinical follow-up after three months and control group will be only submitted to neurological exam, olfactory test, MRI imaging and test their ability to discriminate the essence oils used in olfactory training. As a result, is expected a better understanding of the characteristics of olfactory dysfunction caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus infection, as well as the effectiveness and viability of using Olfactory Training as a therapeutic alternative.

Conditions

• Covid19
• SARS-CoV Infection
• Olfactory Disorder
• Anosmia

Interventions

Type	Name	Description
OTHER	Essence oils	Consists in olfactory training using essence oils

Timeline

• Start date: 2021-05-01
• Primary completion: 2022-05-01
• Completion: 2024-05-01
• First posted: 2021-02-21
• Last updated: 2021-02-21

Locations

1 site across 1 country: Brazil