NCT04764266

Glycocalyx During Normothermic Machine Perfusion

Glycocalyx Damage During Normothermic Graft Perfusion in Orthotopic Liver Transplantation - A Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Medical University Innsbruck · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

An organ intended for transplantation is normally stored on ice (cold storage, CS) after explantation from the donor. During this storage process, damage to the endothelial glycocalyx occurs. It is known from numerous studies that the integrity of the endothelial glycocalyx is necessary for organ function. Normothermic machine perfusion is an alternative storage method for explanted livers, where the graft is perfused with warm blood. This study aims to clarify the influence of normothermic machine perfusion on endothelial glycocalyx damage of the graft.

Conditions

• Glycocalyx
• Liver Transplantation

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Heparansulfate and Syndecan 1	Blood samples will be collected from the patient at 5 different time points. Three perfusate samples will be collected during normothermic machine perfusion (4,9ml each).

Timeline

• Start date: 2021-02-10
• Primary completion: 2023-12-31
• Completion: 2024-02-01
• First posted: 2021-02-21
• Last updated: 2024-03-13

Locations

1 site across 1 country: Austria