NCT04763655

Neural Biomarkers of Electroconvulsive Therapy Response

Neural Biomarkers of Electroconvulsive Therapy Response in Schizophrenia

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (estimated)
• Sponsor: Northwell Health · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

In the proposed study, the investigators will utilize resting-state functional MRI (fMRI) and structural MRI-based electrical field modeling to study the effect of electroconvulsive therapy on human neural circuitry. Our study will recruit patients who are beginning treatment with bilateral electroconvulsive therapy (N=75). Our design will be longitudinal where patients will be followed up until their 8th week electroconvulsive therapy clinically. The primary measure of interest will be the slope of clinical change estimated with mixed effect modeling (see Approach). Secondary measures will be the cognitive performance change between baseline and the 8th week electroconvulsive therapy time point.

Conditions

• Electroconvulsive Therapy Treated Patients

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	clinical and neuropsychological testing	Patients are monitored with Brief Psychiatric Rating Scale (BPRS) weekly and structural and functional MRI and MATRICS battery before and at the end of the course of the study

Timeline

• Start date: 2020-04-01
• Primary completion: 2024-12-01
• Completion: 2025-07-01
• First posted: 2021-02-21
• Last updated: 2024-10-01

Locations

1 site across 1 country: United States