NCT04760912

General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery

Comparison of General Anesthesia With Use of Muscle Relaxation and General Anesthesia Without Muscle Relaxation on Recovery of Muscle Strength of the Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Clinical Hospital Centre Zagreb · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Neuromuscular blocking agents are often used during general anesthesia. Also, general anesthesia may be performed without use of neuromuscular blocking agents. Avoiding neuromuscular relaxation enables better muscle strength recovery.

Detailed description

Rocuronium is well used neuromuscular blocking agent during general anesthesia. Although very often used, neuromuscular blocking agents may sometimes have consequence in form of residual neuromuscular block. Tha aim of the study is to compare influence of rocuronium during general anesthesia on muscle strength recovery measured by hand grip dynamometer. Measuremwnt of hand grip strength is perforrmed before and after general anesthesia. This research should contribute to better choice of anesthesia technique and better quality of patient recovery, as studies so far have not been detaily carried out. Hypothesis of the research is that anesthesia without use of neuromuscular blocking agents may enable better recovery of muscle strength in immediate postoperative period.

Conditions

• Rocuronium
• Muscle Weakness
• General Anaesthesia

Interventions

Type	Name	Description
DRUG	Rocuronium	Rocuronium used for neuromuscular blokade during anesthesia and anesthesia without rocuronium
PROCEDURE	General anesthesia for surgery	General anesthesia with standard anesthetic monitoring,

Timeline

• Start date: 2020-04-01
• Primary completion: 2022-08-20
• Completion: 2022-09-20
• First posted: 2021-02-18
• Last updated: 2026-01-21

Locations

1 site across 1 country: Croatia