NCT04760808

Evaluation of Cerebrospinal Fluid Flow in Adolescent Idiopathic Scoliosis

Evaluation of Cerebrospinal Fluid Flow by MRI in Adolescent Idiopathic Scoliosis, From Its Signaling Through the Study of Trunk Graviception and Proprioception

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 72 (actual)
• Sponsor: Lille Catholic University · Academic / Other
• Sex: Female
• Age: 12 Years – 17 Years
• Healthy volunteers: Accepted

Summary

Adolescent Idiopathic Scoliosis (AIS) is the most frequent spinal deformity in adolescence, but its etiology remains unknown. Recent publications suggest a link between ciliopathy and AIS. More specifically a modification of the cerebro-spinal fluid (CSF) flow by ciliary dysfunction could be at the origin of a scoliotic deformity. This study aims to compare the CSF flow measured by magnetic resonance imaging (MRI) in an AIS group and a control group.

Conditions

• Adolescent Idiopathic Scoliosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Baseline Clinical Examination	Evaluations of Postural control; Subjective postural vertical; Subjective visual vertical; Verticality perception
RADIATION	Initial 3T MRI of the Brain and Spine	Non-injected CSF flow MRI
DIAGNOSTIC_TEST	6-month Follow-up Clinical Examination	Evaluations of Postural control; Subjective postural vertical; Subjective visual vertical; Verticality perception
RADIATION	6-month Follow-up 3T MRI of the Brain and Spine	Non-injected CSF flow MRI

Timeline

• Start date: 2021-02-10
• Primary completion: 2022-05-04
• Completion: 2022-05-04
• First posted: 2021-02-18
• Last updated: 2024-09-19

Locations

2 sites across 1 country: France