NCT04754997

Effect of Exercise in Pediatric Hemophilia

The Effect of Exercise Training on Pain, Physical Activity and Quality of Life in Pediatric Hemophilia Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Hasan Kalyoncu University · Academic / Other
• Sex: Male
• Age: 8 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

This study investigates the effect of exercise training on pain, physical activity and quality of life in pediatric hemophilia patients.

Detailed description

Hemophilia is a congenital X-linked recessive disease characterized by the lack or absence of clotting factors in the blood. Male individuals with problems in the X chromosome are affected, females are carriers. There are two common types, factor VIII (Hemophilia A) and factor IX (Hemophilia B), and the percentage of the exposed factor in circulation determines the degree of hemophilia disease (\<1% severe, 1-5% moderate,\> 20% mild). The most common clinical symptoms in hemophilia are intra-articular and intramuscular spontaneous bleeding, a history of bleeding that lasts longer than expected after trauma, hemarthrosis and hematomas after crawling or walking in children with moderate or severe hemophilia. Pain, swelling, redness, temperature increase and limitation of movement occur in the bleeding joint. Bleeding into the joint space causes inflammation in the synovial membrane and synovitis occurs. With chronic synovitis, the synovial membrane thickens. Degeneration of the joint cartilage and narrowing of the joint space occurs. Hemarthroses constitute 70-80% of bleeding findings. The most common bleeding joints are knee joints with a rate of 45%. Besides pharmacological treatment for joint and muscle bleeding, the most suitable option is exercise therapy. The aim of our study is to examine the effect of exercise agitation on pain, physical activity and quality of life in pediatric hemophilia patients. The results of the study indicate that the exercise protocol developed for the lower extremity in pediatric hemophilia patients will have a positive effect on pain, physical activity and quality of life.

Conditions

• Hemophilia A, Severe
• Hemophilia Arthropathy

Interventions

Type	Name	Description
OTHER	Traditional exercise training	The therapy program will planned for 12 weeks and the sessions will be performed in 45 minutes (min) for 2 days a week. The lower extremity range of motion exercise and strengthening exercises will be applied on the mat 10 repetition. The number of repetitions and type of exercises will be changed every 3 weeks.
OTHER	Specific exercise training	The therapy program will planned for 12 weeks and the sessions will be performed in 45 minutes (min) for 2 days a week. Exercise training consists of lower extremity closed kinetic chain exercises and core exercises. The type of exercise changes every 3 weeks.

Timeline

• Start date: 2021-01-16
• Primary completion: 2021-11-10
• Completion: 2021-11-30
• First posted: 2021-02-15
• Last updated: 2021-02-15

Locations

1 site across 1 country: Turkey (Türkiye)