NCT04754152

Long-term Effect of θ Burst Magnetic Stimulation on Clinical Symptoms of Alzheimer Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Anhui Medical University · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This was a randomized, single-blind, parallel, placebo-controlled clinical trial assessing the efficacy of neuronavigational TBS among patients with AD. Fourty late-onset AD were included in the study, all the patients were divided into TBS groups and drug treatment group. Drug intervention group AD patients with drug regimen (donepezil 5mg / d) and primary care guidance, once every three months follow-up. TBS group is treated with TBS (a course of treatment every 3 months); after completing 4 treatments/follow-ups a year, evaluate the changes in MoCA, other clinical symptoms and multi-domain cognition tests, and brain Changes in structure and function.

Conditions

• Repetitive Transcranial Magnetic Stimulation

Interventions

Type	Name	Description
OTHER	θ burst transcranial magnetic stimulation	In addition to drug therapy, TBS supplementary therapy was given every 3 months.The TBS parameters were as follows: 3 pulses, 50 Hz bursts given every 200 ms (at 5 Hz), and an intensity of 70% of the resting motor threshold, as measured from the right first dorsal interosseous muscle using a handheld 70 mm figure-of-eight coil. Take a course every 10 weeks .
DRUG	Pharmacotherapy	Stable doses of cholinesterase inhibitors were given and the patients were followed up every three months.

Timeline

• Start date: 2021-04-21
• Primary completion: 2022-05-17
• Completion: 2022-12-31
• First posted: 2021-02-15
• Last updated: 2023-02-28

Locations

1 site across 1 country: China