NCT04753892

3Sm Challenge Model Protocol

An Immune Challenge Model Using gp41 3Sm Peptide in Healthy Human Adults to Characterise B Cell Responses to a Model Virus-neutralizing Antibody-inducing Motif in Health Versus Chronic Viral Infection

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The 3Sm challenge study is a small clinical study in eight healthy volunteers who will be injected with a protein which includes a short portion ('3Sm peptide') which is derived from a part (the '3S region') of the coat protein of HIV. The researchers believe that the 3Sm peptide might trigger an immune response which includes rare antibodies able to neutralise a wide range of different strains of HIV. The results will be useful in guiding the development of future vaccines against HIV, and other diseases.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	3SM2-G-CRM197 with squalene adjuvant	Immune challenge agent

Timeline

• Start date: 2021-09-10
• Primary completion: 2022-07-20
• Completion: 2022-07-20
• First posted: 2021-02-15
• Last updated: 2022-07-27

Locations

1 site across 1 country: United Kingdom