NCT04753307

Perioperative Inflammatory Response Assessment in High-risk Patients Undergoing Noncardiac Surgery

Perioperative Inflammatory Response Assessment in High-risk Patients Undergoing Noncardiac Surgery - a Prospective Non-interventional Observational Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 1,400 (estimated)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Not accepted

Summary

Postoperative cardiovascular complications are common after noncardiac surgery. The association between perioperative inflammation and the occurrence of cardiovascular complications after surgery is still unknown. Therefore, we will evaluate as our primary aim the association between patients with increased postoperative inflammation, assessed with C-reactive protein measurements, and the occurrence of major cardiovascular complications after noncardiac surgery. We will further evaluate the influence of perioperative inflammation on the occurrence of postoperative acute kidney injury. We will also evaluate the association between inflammation and the influence on Days-At-Home within 30 days. Furthermore, we will evaluate the association between increased inflammatory biomarkers and postoperative N-terminal pro brain natriuretic peptide (NT-proBNP) concentration.

Conditions

• Postoperative Complications
• Cardiovascular Complication
• Myocardial Ischemia
• Inflammation

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Laboratory measurements	Inflammatory and cardiac biomarkers will be measured before surgery, and on the first, second, third and fifth postoperative day

Timeline

• Start date: 2021-01-19
• Primary completion: 2024-01-31
• Completion: 2025-01-31
• First posted: 2021-02-15
• Last updated: 2023-08-14

Locations

1 site across 1 country: Austria