NCT04752852

Use of Prophylactic Steroids in the Prevention of Post-thyroidectomy Hypocalcaemia and Voice Dysfunction

Randomised Control Trial on the Use of Prophylactic Steroids in the Prevention of Post-thyroidectomy Hypocalcaemia and Voice Dysfunction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 192 (actual)
• Sponsor: Holy Family Hospital, Pakistan · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Total thyroidectomy for benign surgical pathologies is associated with risks related to temporary hypocalcaemia and vocal quality dysfunction. Dexamethasone, as an anti-inflammatory steroid, has been proposed to have a physiological effect on hypocalcaemia and voice quality. Investigators conducted a double-blinded controlled trial to assess the effect of preoperative dexamethasone on the vocal dysfunction and hypocalcaemia following thyroidectomy

Conditions

• Thyroid Diseases
• Hypocalcemia
• Vocal Cord Dysfunction

Interventions

Type	Name	Description
DRUG	Dexamethasone	8 mg/2 ml dexamethasone IV, 60 minutes before the induction of anaesthesia
DRUG	Placebo	2 ml normal saline (0.9%) IV, 60 minutes before the induction of anaesthesia

Timeline

• Start date: 2014-01-01
• Primary completion: 2019-12-01
• Completion: 2020-07-01
• First posted: 2021-02-12
• Last updated: 2021-02-12