NCT04750980

Microbiota and Allergy

Microbiota as Potential Target for Innovative Preventive and Therapeutic Strategies for Food Allergy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: Federico II University · Academic / Other
• Sex: All
• Age: 48 Months – 84 Months
• Healthy volunteers: —

Summary

Food allergy derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for gut microbiota in oral tolerance development. An altered composition of gut microbiota results in an unbalanced local and systemic immune response to food allergens. There are qualitative and quantitative differences in gut microbiota composition in children with food allergy. Preliminary results of MATFA study demonstrated gut microbiota in allergic children.These findings support the pivotal role of the gut microbiota in the pathogenesis of allergic diseases and may open new strategies in the development of innovative preventive and therapeutic approaches.

Conditions

• Allergy

Interventions

Type	Name	Description
OTHER	food allergy	food allergy
OTHER	respiratory allergy	respiratory allergy
OTHER	healthy controls	healthy controls

Timeline

• Start date: 2017-06-01
• Primary completion: 2021-01-30
• Completion: 2021-01-30
• First posted: 2021-02-11
• Last updated: 2021-07-27

Locations

1 site across 1 country: Italy