Trials / Recruiting
RecruitingNCT04742608
Development of Liquid Biopsy Technologies for Noninvasive Cancer Diagnostics in Patients With Suspicious Thyroid Nodules or Thyroid Cancer
Isolation and Characterization of Extracellular Vesicles in Patients With Thyroid Nodules and Thyroid Cancer
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 250 (estimated)
- Sponsor
- Jonsson Comprehensive Cancer Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study is being done to help researchers learn more about and successfully diagnose cancer using blood samples and tissue samples from surgeries in patients with suspicious thyroid nodules or thyroid cancer. Diagnosing cancer in this way, as opposed to biopsies, may be less invasive to the patient. Analyzing blood and tissues samples may also help researchers to differentiate non-cancerous tumors from thyroid cancer and detect high-risk mutations to guide treatment.
Detailed description
PRIMARY OBJECTIVE: I. Sensitivity and specificity of molecular profile of thyroid derived extracellular vesicles (EVs) as predictor of thyroid cancer. SECONDARY OBJECTIVES: I. Quantity of thyroid derived EVs captured in various stages of thyroid cancer. II. Whether quantity of EVs decreases in proportion to response to therapy in thyroid cancer patients. III. Optimal ribonucleic acid (RNA)/deoxyribonucleic acid (DNA) panel in thyroid tumor derived EVs to diagnose thyroid cancer. OUTLINE: Patients undergo collection of blood samples on the day of surgery following anesthesia but prior to incision and approximately 4-6 weeks after surgery. Patients who undergo remnant ablation after total thyroidectomy with radioactive iodine have an additional blood sample collected. Patients also undergo collection of tissue samples following surgical resection of the thyroid. Patients' medical records are also reviewed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Biospecimen Collection | Undergo collection of blood and tissue samples |
| OTHER | Electronic Health Record Review | Medical charts are reviewed |
Timeline
- Start date
- 2020-02-21
- Primary completion
- 2025-06-09
- Completion
- 2027-02-01
- First posted
- 2021-02-08
- Last updated
- 2026-03-10
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT04742608. Inclusion in this directory is not an endorsement.