NCT04742348

Research on Translational Outcomes of Alcohol (Project RETRO)

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 21 Years – 24 Years
• Healthy volunteers: Accepted

Summary

The primary aim of the current study is to assess the effect of a single dose of carbidopa-levodopa on ad libitum alcohol consumption and alcohol craving in young adults with a history of binge drinking.

Detailed description

This is a small (N = 42) 2-arm, double-blind, randomized controlled pilot study to assess the effect of a single dose of immediate release carbidopa-levodopa (50mg/500mg) to acutely reduce alcohol consumption and craving in college students with a history of heavy episodic drinking. Participants will be between 21-24 years old from 2- and 4- year colleges in the Seattle Metropolitan area. Interested students will contact the study line and provide verbal consent to be sent a link to an online screening survey. Eligible participants will be scheduled to come in for the ad libitum alcohol administration. Participants will receive either the carbidopa-levodopa or a placebo and complete the alcohol administration protocol.

Conditions

• Alcohol Drinking

Interventions

Type	Name	Description
DRUG	Carbidopa Levodopa	Participants who are randomized to active drug group will receive 1 dose of immediate release carbidopa-levodopa (50mg/500mg) .
DRUG	Placebo	Participants who are randomized to placebo group will be provided with similar looking tablet(s) as the active drug.

Timeline

• Start date: 2023-02-01
• Primary completion: 2023-08-01
• Completion: 2023-08-01
• First posted: 2021-02-08
• Last updated: 2023-02-13

Regulatory

• FDA-regulated drug study