NCT04739631

Efficacy of Acupuncture on Chemotherapy-Induced Peripheral Neuropathy

Efficacy of Acupuncture on Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Phase III, Randomized, Sham-controlled Clinical Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 94 (estimated)
• Sponsor: Taipei Veterans General Hospital, Taiwan · Other Government
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess the neurological efficacy of acupuncture in patients with cancer who experienced peripheral neuropathy, which is induced by chemotherapy.

Detailed description

Background: Chemotherapy may lead to peripheral neuropathy up to 40% in cancer survivors, especially in some types of patients with cancer. The effect of acupuncture, an ancient Chinese medicine technique, was recognized by the World Health Organization (WHO) in the treatment of several diseases. The postulated mechanisms associated with acupuncture in analgesia or neurogenesis are still under investigation. Considering a moderate recommendation for duloxetine in the treatment of chemotherapy-induced peripheral neuropathy (CIPN) based on based on neuropathic pain, and a few treatment options with evidence for CIPN, acupuncture might be another option. Nowadays, only small scale pilot studies provided initial proof of acupuncture in CIPN, particularly in decreasing neuropathic pain and improving neurotoxicity, the study aims to determine the beneficial effects of acupuncture on CIPN with a large-scale, multicenter, randomized sham-controlled clinical trial. Furthermore, the aim of the study will provide evidence for the clinical therapeutic guideline of CIPN in the future.

Conditions

• Chemotherapy-Induced Peripheral Neuropathy (CIPN)

Interventions

Type	Name	Description
OTHER	acupuncture	use disposable sterile needles to insert to the acupuncture point
OTHER	minimal acupuncture	The sham-controlled group will be performed with minimal acupuncture(superficial needling) at non- acupoints.

Timeline

• Start date: 2021-01-22
• Primary completion: 2022-06-30
• Completion: 2022-06-30
• First posted: 2021-02-04
• Last updated: 2021-04-27

Locations

1 site across 1 country: Taiwan