NCT04738266

Unmasking the Prevalence of AC in an Unselected Echocardiographic Population

A National Survey of Prevalence and Accuracy of Echocardiographic Red Flags of Amyloid Cardiomyopathy in Consecutive Patients Undergoing Routine Echocardiography.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 381 (actual)
• Sponsor: University of Trieste · Academic / Other
• Sex: All
• Age: 55 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate the prevalence of echocardiographic red-flags of amyloid cardiomyopathy (AC) in patients undergoing clinically-indicated echocardiography (observational phase) and the prevalence of AC among AC-suggestive echocardiograms (interventional phase).

Detailed description

Prospective multicenter Italian survey consisting of two phases: observational (echocardiographic screening for amyloid cardiomyopathy among patients ≥ 55 years undergoing clinically-indicated echocardiography) and interventional (specific clinical and instrumental work-up to detect the prevalence of amyloid cardiomyopathy among amyloid cardiomyopathy-suggestive echocardiograms).

Conditions

• Amyloid Cardiomyopathy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Amyloid Cardiomyopathy	Echocardiographic red flags of Amyloid Cardiomyopathy to guide the suspicion of disease and to proceed with second level diagnostic work up including cardiac scintigraphy with bone tracers and search of monoclonal component in serum and urine

Timeline

• Start date: 2020-11-20
• Primary completion: 2021-01-20
• Completion: 2021-07-25
• First posted: 2021-02-04
• Last updated: 2021-02-04

Locations

16 sites across 1 country: Italy