NCT04736290

NLR and PRL in Neurocognitive Disorders

The Effect of NLR and PLR on Perioperative Neurocognitive Disorders in Patients Undergoing Elective Non-cardiac Surgery Under General Anesthesia.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 288 (estimated)
• Sponsor: University of Thessaly · Academic / Other
• Sex: All
• Age: 45 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Preliminary evidence suggest a possible relationship between Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) and perioperative neurocognitive disorders (NCD). We are going to investigate whether the values of NLR and PLR in patients undergoing elective non-cardiac surgery under general anesthesia, are related with increased risk of perioperative NCD.

Detailed description

It is estimated that approximately 10% of elderly undergoing surgery will develop cognitive changes perioperatively, while in some reports the incidence rises up to 80%. Despite the reported high prevalence of perioperative neurocognitive disorders (NCD), their exact etiology is still largely unknown. Preliminary evidence suggest a possible relationship between Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) and perioperative neurocognitive disorders (NCD). We are going to investigate whether the values of NLR and PLR in patients undergoing elective non-cardiac surgery under general anesthesia, are related with increased risk of perioperative NCD.

Conditions

• Neurocognitive Disorders
• Neutrophil-Lymphocyte Ratio
• Platelet-Lymphocyte Ratio

Interventions

Type	Name	Description
OTHER	NLR	Calculation of NLR
OTHER	PLR	Calculation of PLR

Timeline

• Start date: 2015-12-01
• Primary completion: 2021-12-01
• Completion: 2021-12-30
• First posted: 2021-02-03
• Last updated: 2021-04-28

Locations

1 site across 1 country: Greece