NCT04735965

Comparison of Dexmedetomidine and Meperidine for the Prevention of Shivering Following Coronary Artery Bypass Graft

Comparison of Dexmedetomidine and Meperidine for the Prevention of Shivering Following Coronary Artery Bypass Graft: Study Protocol of a Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: Qianfoshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study aims to compare the effects of dexmedetomidine and meperidine on the incidence of shivering in patients undergoing CABG.

Detailed description

Shivering is a common complication in the postoperative period. The incidence of shivering has been reported to range from 5% to 65% under general anesthesia and as 33% during epidural anesthesia. Shivering can increase perioperative risk in patients. Both dexmedetomidine and meperidine are effective agents for the prevention of postanesthetic shivering. However, few studies have compared the anti-shivering effects of different agents following coronary artery bypass graft (CABG). This study aims to compare the effects of dexmedetomidine and meperidine on the incidence of shivering in patients undergoing CABG.

Conditions

• Coronary Artery Disease
• Postoperative Shivering

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Dexmedetomidine would be intravenously infused at a dose of 1μg/kg over 15 minutes 30 min before the end of surgery
DRUG	Meperidine	Meperidine would be intravenously injected at a dose of 0.5mg/kg 30 min before the end of surgery
DRUG	Placeb	Equal volume of normal saline to dexmedetomidine and meperidine group.

Timeline

• Start date: 2021-07-15
• Primary completion: 2022-07-01
• Completion: 2022-08-01
• First posted: 2021-02-03
• Last updated: 2022-01-10

Locations

1 site across 1 country: China