NCT04731415

Physiologic Change of Posterior Ocular Segment During Pregnancy

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 69 (estimated)
• Sponsor: Khon Kaen University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Women's physiology changes markedly during normal pregnancy. The most distinct alterations occur in the hormonal and cardiovascular systems. There is a dramatic increase in both estrogen and progesterone. Blood volume starts to increase in the first gestational period and reaches a peak in the third trimester. The physiologic ocular changes during pregnancy are mainly the result of hormonal and blood volume increase, and then are usually marked in the third trimester.

Detailed description

Ocular anterior segment changes during pregnancy are the followings * Melanogenesis of eyelid and facial skin -\> melasma * Cellular alteration of lacrimal and meibomian gland -\> dry eye symptoms * Increased corneal thickness and corneal curvature -\> contact lens intolerance * Increased lens thickness -\> loss of accommodation * Decreased intraocular pressure -\> better glaucoma control There are few studies of posterior changes in pregnant women. Many limitations of previous publications includes lack of internal control and no data of postpartum contraception. However, choroidal thickness seems to be thicker in pregnant women than non-pregnant women. The other changes are non-inclusive.

Conditions

• Retinal Vascular

Interventions

Type	Name	Description
DEVICE	Optical coherence tomography and optical coherence tomography angiography (Optovue®)	Optical coherence tomography and optical coherence tomography angiography (Optovue®) were performed in each trimesters and at 6 weeks after childbirth. 1. st trimester : gestational age 8-12 weeks 2. nd trimester : gestational age 24-28 weeks 3. rd trimester : gestational age 34-38 weeks

Timeline

• Start date: 2021-07-01
• Primary completion: 2025-12-30
• Completion: 2026-06-30
• First posted: 2021-02-01
• Last updated: 2021-06-30

Locations

1 site across 1 country: Thailand