Trials / Completed
CompletedNCT04727879
Immunopathology of Polymyalgia Rheumatica on Shoulder Bursae's Biopsies
Beyond Analysis Of Blood Sample, to Approach Immunopathology of Polymyalgia Rheumatica on Shoulder Bursae's Biopsies: the BAOBAB Study
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 20 (actual)
- Sponsor
- University Hospital, Brest · Academic / Other
- Sex
- All
- Age
- 50 Years
- Healthy volunteers
- Not accepted
Summary
The work carried out at the Brest University Hospital on serum immunological changes in patients with polymyalgia rheumatica (PMR) (based on clinical protocols TENOR, SEMAPHORE, THEN) made it possible to describe the changes in the distribution of lymphocyte subpopulations and cytokine levels during PPR, before and then under treatment compared to controls. However, in systemic autoimmune or inflammatory pathologies, serum immunological mechanisms are rarely a reflection of intra-tissue mechanisms. In the specific case of PMR, there are few data concerning muscular or joint immunological modifications. The investigators now wish to study the immunological modifications occurring at the tissue sites of interest, in particular in the shoulder bursae
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Synovial membrane biopsy with puncture of synovial fluid | The biopsy of the shoulder bursae will be carried out thanks to a device Tru-cut (Tru-Cut Biopsy Needle), minimally invasive, introduced, as during an infiltration, within the bursa serosa. |
| PROCEDURE | Joint fluid sampling | In case of associated peripheric arthritis, the patient will also be offered a sample of joint fluid during a cortisonic infiltration for analgesic purposes, performed as part of routine care. |
| PROCEDURE | Blood sample | A blood sample taken during routine care and unused will also be collected from patients and controls for immunoassays. |
Timeline
- Start date
- 2021-04-07
- Primary completion
- 2022-07-13
- Completion
- 2022-08-13
- First posted
- 2021-01-27
- Last updated
- 2023-08-01
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT04727879. Inclusion in this directory is not an endorsement.