Trials / Completed
CompletedNCT04724096
Evaluation of OE-MRI in Patients With H&N Cancer
Evaluation of Oxygen Enhanced Magnetic Resonance Imaging for Identification of Hypoxia Induced Resistant Tumours in Patients With Head and Neck Cancer
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 25 (actual)
- Sponsor
- Nottingham University Hospitals NHS Trust · Academic / Other
- Sex
- All
- Age
- 18 Years – 99 Years
- Healthy volunteers
- Accepted
Summary
Assessment of the use of oxygen enhanced MRI scanning in a cohort of patients with head and neck squamous cell carcinomas to identify areas of hypoxia with tumours and relate this to treatment outcomes.
Detailed description
Oxygen-enhanced MRI (OE-MRI) is a technique being actively investigated for imaging hypoxia within cancer tissues. Preliminary clinical data demonstrates the feasibility of using this methodology to study patients with head and neck squamous cell carcinoma (HNSCC). The investigators wish to investigate using this methodology to identify hypoxic subvolumes within HNSCC that may have greater resistance to standard radiotherapy treatment and investigate the association of such hypoxic regions with treatment outcomes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Oxygen Enhanced MRI scan | Dynamic MRI scanning switching from breathing room air to high concentration oxygen part way through the scan. |
Timeline
- Start date
- 2021-03-04
- Primary completion
- 2022-11-28
- Completion
- 2023-02-01
- First posted
- 2021-01-26
- Last updated
- 2023-05-06
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT04724096. Inclusion in this directory is not an endorsement.