NCT04722354

Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: AdventHealth Translational Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the effects of oral abscisic acid (ABA) on glucose metabolism in subjects with defined prediabetes.

Conditions

• Pre Diabetes

Interventions

Type	Name	Description
OTHER	Hyperinsulemic euglycemic clamp	Following a 12-hour overnight fast at the CRU (including abstinence from caffeine containing foods and beverages), insulin sensitivity will be measured using the criterion method of the euglycemic clamp. Participants will have not performed vigorous physical activity for at least the previous 24 h, and be free of acute illness for the prior 2 weeks. An intravenous catheter will be placed in an antecubital vein for subsequent insulin (40 mU/m2-min) and glucose infusions and for stable isotope (6, 6-2H2) infusions to measure insulin sensitivity.
PROCEDURE	Muscle Biopsy	One biopsy taken prior to clamp and a second biopsy taken 30-45 min after the start of the clamp. A biopsy of the Vastus Lateralis muscle will be performed on the leg/thigh using the Bergstrom technique.
DIETARY_SUPPLEMENT	Oral abscisic acid (ABA)	Those in this group will receive ABA (95 µg ABA and 300 mg of corn starch)
OTHER	Placebo	Those in this group will receive placebo (300 mg cornstarch)

Timeline

• Start date: 2021-03-08
• Primary completion: 2024-08-26
• Completion: 2025-12-01
• First posted: 2021-01-25
• Last updated: 2026-03-09
• Results posted: 2026-03-09

Locations

1 site across 1 country: United States