NCT04722276

Fraction of Oxygen on Induction of Anesthesia in Infants

The Effect of Positive End-expiratory Pressure During Induction of General Anesthesia and Non-hypoxic Apnea Time in Infants: a Randomized Controlled Trials

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 84 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 1 Month – 12 Months
• Healthy volunteers: Not accepted

Summary

Invesetigators evaluated the effect of positive end-expiratory pressure during anaesthesia induction on nonhypoxic apnoea time in infants. Invesetigators assigned infants to a 7 cmH2O positive end expiratory pressure (PEEP) with fraction of inspired oxygen 80% or 0 cmH2O PEEP with fraction of oxygen 80% group. Anaesthesia was induced with 0.02 mg kg atropine, 5 mg kg thiopental sodium and 3 to 5% sevoflurane, and neuromuscular blockade with 0.6 mg kg rocuronium. Thereafter, 80% oxygen was provided via face mask with volume-controlled ventilation of 6 ml kg tidal volume, and either 7 cmH2O or no positive end-expiratory pressure. After 3 min of ventilation, the infants' trachea was intubated but disconnected from the breathing circuit, and ventilation resumed when pulse oximetry reached 95%.

Conditions

• Apnea

Interventions

Type	Name	Description
OTHER	positive end expiratory pressure	7cmH2O of positive end expiratory pressure with fraction of inspired oxygen 80% applied during induction of anesthesia
OTHER	fraction of inspired oxygen 80%	fraction of inspired oxygen 80% applied during induction of anesthesia

Timeline

• Start date: 2021-02-01
• Primary completion: 2023-07-01
• Completion: 2023-07-01
• First posted: 2021-01-25
• Last updated: 2023-11-07

Locations

1 site across 1 country: South Korea