NCT04717843

Identification of New Markers of Atrial Myopathy in Patients With Embolic Stroke of Undetermined Source (ESUS) From MRI 4D Data

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Atrial myopathy is considered to be the underlying cause of a large proportion of embolic strokes of undetermined source. However, the definition of this atrial condition is not well delineated while its identification could lead to prescription on anticoagulation in order to avoid stroke recurences. This study aims to identify new markers of atrial myopathy and choosed a multi parametric approach with electrical, echographical, biological and 4D flow CMR derived markers.

Conditions

• Embolic Stroke of Undetermined Source

Interventions

Type	Name	Description
OTHER	4D Flow MRI	Acquisitions of MR imagining with special contrast phase CMR sequences. There is no need for agent contrast injection. The CMR is performed at the time of inclusion.
OTHER	Medical consultation with 12 leads ECG	Collection of medical history, treatment, physical examination and realization of a 12 leads ECG.
OTHER	Holter ECG	48 hours ECG recording
OTHER	Trans thoracic echocardiography	Trans thoracic echocardiography with standard measures performes in the core lab.
BIOLOGICAL	Blood sample	Blood sample in a peripheral vein, send to medical laboratory to dosage of NT pro BNP and troponin serum level.
OTHER	Standard MRI	Acquisitions of MR imagining

Timeline

• Start date: 2021-03-01
• Primary completion: 2024-09-01
• Completion: 2024-09-01
• First posted: 2021-01-22
• Last updated: 2023-09-21

Locations

3 sites across 1 country: France